Tyrosine-67 in cytochrome c is a possible apoptotic trigger controlled by hydrogen bonds via a conformational transition.
نویسندگان
چکیده
We found that cyt c Y67H and Y67R variants represent a state which resembles the conformational intermediate state in cyt c with high peroxidase activity; and also the hydrogen bond network around Tyr67 is associated with the conformational transition of cyt c; these suggest that the hydrogen bond network around Tyr67 is essential in maintaining the cyt c functioning not only as an electron transfer protein but also probably as a trigger in apoptosis.
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ورودعنوان ژورنال:
- Chemical communications
دوره 30 شماره
صفحات -
تاریخ انتشار 2009